The Parkinson´s disease story

How to understand your disease of aging : ageless man 

AGELESS MAN in short

 AMAZON 2017-2022 AGELESS MAN  

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Parkinson's disease (in short)

Our movements are partly ordened by a biochemical substance, the dopamine, secreted by specialized cells from a center located in brain's base (black substance, also said locus niger).

When those cells which secretes dopamine die or are damaged, one sees appearing the symptoms of Parkinson's disease.

Parkinson's disease symptoms
Mobility symptoms	Non mobility symptoms
shakings muscular rigidity slowness of movements balance troublesshakings	constipation disturbed sleep urgencies to urinate	fatigue depression  memory disorders dizzynesses

 

Parkinson's disease treatment
It exists no curative treatment against Parkinson's disease
Dopamine treatment	Inhibitors mono amine oxydase *	Exceptional treatments
Agonists of dopamine Dopamine (L.Dopa)		Surgical treatment (Deep cerebral stimulation) Stem cells. (Research)

*An inhibitor of mono amine oxydase (IMAO) is a molecule which blocks the degrading dopamine  enzyme.

An old publication going back to 1974 deserves our attention. It is about a clinical study evaluating the action of testosterone on  activity of mono amino oxydase in depressed patients.

Conclusion of this study : Testosterone given in apropriate amounts lowers naturally the MAO (Mono amino oxydase) preventing the degradation of dopamine (1)

Mean MAO activity  (monoamine oxydase) in plasma
Before treatment	7223 ± 3740
After treatment	1997 ± 1250 (p<0,01)
400 mgrs. testosterone cipìonate every 21 days

Effect of a treatment with testosterone on the activity of the plasmatic MAO in 7 depressed men (according to Klaiber and coll) (1)

From there the interest to study the  daily androgens' production among patients presenting a Parkinson's disease with the aim of substituting their missing androgens in order to save their production of dopamine.

1. KLAIBER E.L., BROVERMAN D.M., VOGEL W., KOBAYASHI Y. The use of steroid hormones in depression. in Psychotropic action of hormones. Proceedings of the World Cogress of biological psychiatry. Buenos Aires. Argentina, september 1974. Spectrum publications INC.